The most evident and likely functionally impacting change of the lambda variant is represented by the 246-252 deletion since they could confer to the virus an enhancing capacity to escape the host immune response by...
..two theoretic though likely and already reported strategies: shortening epitopes located in the loops and exploiting increased glycosylation variations in spike cell epitopes and glycosylation profile during virus transmission have been already described."
Abstract This manuscript concisely reports an in-silico study on the potential impact of the Spike protein mutations on immuno-escape ability of SARS-CoV-2 lambda variant. Biophysical and bioinformatics data suggest that a combination of shortening immunogenic epitope loops and generation of potential N-glycosylation sites may be a viable adaptation strategy potentially allowing this emerging viral variant escaping host immunity.
Competing Interest Statement
The authors have declared no competing interest.
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