he goal of the CARE project is to deliver treatments for the current COVID-19 outbreak as well as future coronavirus outbreaks.
Part of the project will focus on ‘repurposing’, in which drugs designed for other diseases are ‘repurposed’ for a new disease. Because a lot of work has already been carried out on these compounds, repurposing can deliver relatively rapid results.
The project also aims to deliver new drugs designed specifically to treat COVID-19 and other coronaviruses. To identify potential drugs, the project will screen 600 000 compounds across different libraries. They will also investigate antibodies capable of neutralising the virus.
Potential drugs identified by the project will undergo a range of laboratory tests to refine their design and evaluate and improve their safety and efficacy. Compounds that make the grade will enter clinical trials, where their safety and efficacy will be tested in humans.
The CARE project is committed to the FAIR (findable, accessible, interoperable, reusable) principles of open science and will share its scientific results through open access platforms and peer-reviewed journals, as well as via relevant conferences and other events. The team will also work closely with other, similar projects.
Ultimately, CARE should both contribute to the world’s response to the current COVID-19 outbreak, and ensure we are better prepared for further coronavirus outbreaks in the future.
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